Articolo in rivista, 2013, ENG, 10.1002/macp.201200476

New Amphiphilic Conjugates of Amino-Poly(ethylene glycols) With Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers

Pignatello Rosario; Pantò Valentina; Impallomeni Giuseppe; Carnemolla Giovanni Marco; Carbone Claudia; Puglisi Giovanni

Univ Catania, Dipartimento Sci Farmaco, I-95125 Catania, Italy

Poly(ethylene glycol) (PEG2000) polymers containing one or two amine residues are linked to a-lipoamino acids (LAA) to produce mono- and homo-disubstituted PEGLAA conjugates as new materials for the surface coating of colloidal drug carriers. Conjugates are characterized by FT-IR, 1H-NMR, and MALDITOF mass spectrometry. Differential scanning calorimetry studies are performed to assess the interaction of PEG2000LAAs with a biomembrane model (dipalmitoylphosphatidylcholine multilamellar liposomes). Whereas the parent PEGs affect only the superficial structure of the bilayers, the amphiphilic PEGLAA conjugates exert a modulated perturbing effect on the thermotropic profile of liposomes. A molar concentration between 5% and 10% is individuated as the more suitable to produce stable vesicles.

Macromolecular chemistry and physics (Print) 214 (1), pp. 46–55

Keywords

amphiphiles, differential scanning calorimetry, long-circulating drug carriers, nanocarriers, supramolecular structures

CNR authors

Impallomeni Giuseppe

CNR institutes

ICTP – Istituto di chimica e tecnologia dei polimeri, IPCB – Istituto per i Polimeri, Compositi e Biomateriali