Rapporto di progetto (Project report), 2014, ITA
Caudai C.
CNR-ISTI, Pisa, Italy;
This document reports part of the WP1-ISTI unit activity in the framework of the national Flagship Project InterOmics, on the 3D chromatin structure analysis from Hi-C experiments. Compared with other methods presented in the literature, our approach uses a new solution model incorporating sound prior knowledge, and a new reconstruction criterion that does not require an explicit translation of the Hi-C data into Euclidean distances between pairs of genomic loci. This approach also allows us to solve the problem in a multiscale setting, by reconstructing significant fragments separately at high resolution and then putting them together through the same criterion applied to lower-resolution data.
Epigenetics, 3D chromatin structure, Chromosome conformation capture, J.3 LIFE AND MEDICAL SCIENCES. Biology and Genetics
ISTI – Istituto di scienza e tecnologie dell'informazione "Alessandro Faedo"
ID: 279354
Year: 2014
Type: Rapporto di progetto (Project report)
Creation: 2014-03-26 13:20:38.000
Last update: 2020-12-19 19:21:44.000
CNR authors
External IDs
CNR OAI-PMH: oai:it.cnr:prodotti:279354