Rapporto di progetto (Project report), 2014, ITA

Ricostruzione tridimensionale della struttura della cromatina da dati tipo Chromosome Conformation Capture. Nota riservata, progetto InterOmics

Caudai C.

CNR-ISTI, Pisa, Italy;

This document reports part of the WP1-ISTI unit activity in the framework of the national Flagship Project InterOmics, on the 3D chromatin structure analysis from Hi-C experiments. Compared with other methods presented in the literature, our approach uses a new solution model incorporating sound prior knowledge, and a new reconstruction criterion that does not require an explicit translation of the Hi-C data into Euclidean distances between pairs of genomic loci. This approach also allows us to solve the problem in a multiscale setting, by reconstructing significant fragments separately at high resolution and then putting them together through the same criterion applied to lower-resolution data.

Keywords

Epigenetics, 3D chromatin structure, Chromosome conformation capture, J.3 LIFE AND MEDICAL SCIENCES. Biology and Genetics

CNR authors

Caudai Claudia

CNR institutes

ISTI – Istituto di scienza e tecnologie dell'informazione "Alessandro Faedo"

ID: 279354

Year: 2014

Type: Rapporto di progetto (Project report)

Creation: 2014-03-26 13:20:38.000

Last update: 2020-12-19 19:21:44.000

CNR authors

External links

OAI-PMH: Dublin Core

OAI-PMH: Mods

OAI-PMH: RDF

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:279354