Articolo in rivista, 2012, ENG, 10.1007/s00259-012-2117-9

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

Marciano, Caterina; Galderisi, Maurizio; Gargiulo, Paola; Acampa, Wanda; D'Amore, Carmen; Esposito, Roberta; Capasso, Enza; Savarese, Gianluigi; Casaretti, Laura; Lo Iudice, Francesco; Esposito, Giovanni; Rengo, Giuseppe; Leosco, Dario; Cuocolo, Alberto; Perrone-Filardi, Pasquale

University of Naples Federico II; University of Naples Federico II; Consiglio Nazionale delle Ricerche (CNR); University of Naples Federico II; SDN Fdn

We assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD).In this prospective study, 23 patients with type 2 diabetes and 26 nondiabetic patients matched for age, sex and other cardiovascular risk factors underwent a cold pressure test (CPT) and dipyridamole transthoracic echocardiography to determine their coronary flow (CF) ratio. Within 2 weeks, all diabetic patients also underwent dipyridamole-rest myocardial perfusion single-photon emission (MPS) CT. None of the patients with or without diabetes had significant CAD on invasive coronary angiography.

European journal of nuclear medicine and molecular imaging (Print) 39 (7), pp. 1199–1206

Keywords

Type 2 diabetes mellitus, Microvascular dysfunction, Myocardial perfusion imaging

CNR authors

Cuocolo Alberto, Acampa Wanda

CNR institutes

IBB – Istituto di biostrutture e bioimmagini