Poster, 2016, ENG

A tissue engineering strategy using placental mesenchymal stem cells hosted on RKKP glass-ceramic for bone regenerative medicine applications

Ledda M., Fosca M., De Bonis A., Lolli M.G:, Bertani F:R:, Teghil R., De Stefanis A., Marchese R

Institute of Translational Pharmacology (IFT-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy Istituto di Struttura della Materia (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy

In tissue engineering protocols, the survival of transplanted stem cells is a limiting factor that could be overcome using a cell delivery matrix able to support cell proliferation and differentiation. With this aim, using human amniotic mesenchymal stromal stem cells (hAMSCs) from placenta, the cell-friendly and biocompatible behavior of RKKP glass-ceramic coated Titanium (Ti) surface was studied. The glass-ceramic material was prepared by sol-gel synthesis procedure and then deposited onto the Ti surface by Pulsed Laser Deposition method. Our findings demonstrated that the RKKP coated Ti supports are cell-friendly substrates and the combination of the hAMSCs' properties together with the bioactive characteristics of RKKP glass-ceramics may be used as a new potential tool for bone tissue engineering and regenerative medicine applications

Biomaterials for Healthcare (BioMaH), Rome, Italy, 17-20 October 2016

Keywords

tissue engineering, RKKP glass-ceramic, regenerative medicine

CNR authors

Fosca Marco, Lolli Maria Grazia, Lisi Antonella, Ledda Mario, Bertani Francesca Romana, Rau Dzhulietta

CNR institutes

IFT – Istituto di Farmacologia Traslazionale