Articolo in rivista, 2017, ENG, 10.1186/s12944-017-0414-9

y The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil

Hals, Petter-Arnt; Wang, Xiaoli; Piscitelli, Fabiana; Di Marzo, Vincenzo; Xiao, Yong-Fu

Aker Biomarine Antarctic AS; Crown Biosci Taicang Inc; ICB-CNR

Background: A commonly used measure to reflect the intake of the long-chain omega-3 fatty acids EPA and DHA is the omega-3 index, defined as the sum of EPA + DHA as % of total fatty acids in erythrocyte membrane. When the omega-3 index changes it follows that the relative fractions of other fatty acids in the membrane are also changed. In the present study, increasing doses of a preparation of omega-3 rich phospholipids extracted from krill oil were administered orally to non-human primates for 12 weeks and the time course of EPA, DHA and 22 other fatty acids in erythrocytes was determined bi-weekly during treatment and for 8 weeks after cessation of treatment. Plasma concentrations of six endocannabinoid-type mediators being downstream metabolites of some fatty acids analyzed in erythrocytes were also determined.

Lipids in health and disease 16

Keywords

Phospholipids, Long-chain omega-3 fatty acids, EPA, DHA, Omega-3 index, Endocannabinoids

CNR authors

Di Marzo Vincenzo, Piscitelli Fabiana

CNR institutes

ICB – Istituto di chimica biomolecolare