Articolo in rivista, 2015, ENG, 10.3390/nu7075246

Ferulic Acid: from the plants a hope for Alzheimer's Disease therapy

Sgarbossa A.; Giacomazza D.; Di Carlo M.

NEST Istituto Nanoscienze CNR and Scuola Normale Superiore, Piazza S. Silvestro 12, Pisa 56127, Italy; Istituto di Biofisica (IBF) CNR, Via U. La Malfa 153, Palermo 90146, Italy; Istituto di Biomedicina ed Immunologia Molecolare (IBIM) CNR, Via U. La Malfa 153, Palermo 90146, Italy

Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (A) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. A is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in oligomer and fibril forms. Inhibition of the formation of A fibrils as well as the destabilization of preformed A in the Central Nervous System (CNS) would be an attractive therapeutic target for the treatment of AD. Moreover, a large number of studies indicate that oxidative stress and mitochondrial dysfunction may play an important role in AD and their suppression or reduction via antioxidant use could be a promising preventive or therapeutic intervention for AD patients. Many antioxidant compounds have been demonstrated to protect the brain from A neurotoxicity. Ferulic acid (FA) is an antioxidant naturally present in plant cell walls with anti-inflammatory activities and it is able to act as a free radical scavenger. Here we present the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models.

Nutrients 7 (7), pp. 5764–5782

Keywords

Alzheimer's Disease, Antioxidants, Fibrillogenesis, Oxidative stress, Apoptosis, Nanotechnology

CNR authors

Di Carlo Marta, Sgarbossa Antonella, Giacomazza Daniela

CNR institutes

IBIM – Istituto di biomedicina e di immunologia molecolare "Alberto Monroy", NANO – Istituto Nanoscienze

ID: 394421

Year: 2015

Type: Articolo in rivista

Creation: 2018-11-27 07:46:22.000

Last update: 2021-04-21 14:01:04.000

External links

OAI-PMH: Dublin Core

OAI-PMH: Mods

OAI-PMH: RDF

DOI: 10.3390/nu7075246

URL: https://www.mdpi.com/2072-6643/7/7/5246

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:394421

DOI: 10.3390/nu7075246

Scopus: 2-s2.0-84937422538