CNR ExploRA

Articolo in rivista, 2019, ENG, 10.1002/admt.201800350

Coupling Cortical Neurons through Electronic Memristive Synapse

Juzekaeva E.; Nasretdinov A.; Battistoni S.; Berzina T.; Iannotta S.; Khazipov R.; Erokhin V.; Mukhtarov M.

Laboratory of Neurobiology, Institut of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya 18, Kazan, 420008, Russian Federation; Institute of Materials for Electronics and Magnetism, Italian National Council of Research (CNR-IMEM), Parco Area delle Scienze, 37A, Parma, 43124, Italy; INMED INSERM UMR1249, Aix-Marseille University, 163 Avenue de Luminy, BP 13, Marseille Cedex 09, 13273, France

Functional coupling live neurons through artificial synapses is the primary requirement for their implementation as prosthetic devices or in building hybrid networks. Here, the first evidence of unidirectional, activity dependent, coupling of two live neurons in brain slices via organic memristive devices (OMD) is demonstrated. ODM is a polymeric electrochemical element, which has two terminals for the connection in electrical circuits and which displays hysteresis and rectifying features. OMD coupling is characterized by nonlinear relationships determined by the instantaneous values of OMD resistance that can be controlled by the neuronal activity, and the excitation threshold in the postsynaptic neuron. OMD coupling also has the spike-timing features similar to that of the natural excitatory synapses. Also, OMD-synapses support synchronized delta-oscillations in the two-neuron network. It is proposed that OMD-synapses may enable realization of prosthetic synapses and building hybrid neuronal networks endowed with a capacity of learning, memory, and computation.

Advanced materials (Weinh., Print) 4 (1), pp. 1800350-1–1800350-6