Articolo in rivista, 2018, ENG, 10.2174/1871520618666180209151750

Caffeine Effect on HIFs/VEGF Pathway in Human Glioblastoma Cells Exposed to Hypoxia

Maugeri, Grazia; D'Amico, Agata G.; Rasa, Daniela M.; Saccone, Salvatore; Federico, Concetta; Magro, Gaetano; Cavallaro, Sebastiano; D'Agata, Velia

Univ Catania; San Raffaele Open Univ Rome; Univ Catania; Univ Catania; CNR

Background: Caffeine represents the most used psychoactive drug in the world acting through different mechanisms of action and on several molecular targets. It exerts an anti-cancer role in glioblastoma multifonne (GBM). This neoplasia is characterized by extensive hypoxic foci triggering hypoxia-inducible factors (HIFs) expression. Among these factors, HIF-1 alpha performs a crucial role in the induction of vascular endothelium growth factor (VEGF), a key player in angiogenesis and cell migration.

Anti-cancer agents in medicinal chemistry (Print) 18 (10), pp. 1432–1439

Keywords

Caffeine, glioblastoma multiforme, hypoxia-inducible factors, vascular endothelium growth factor, PI3K/Akt, MAPK/ERK

CNR authors

Cavallaro Sebastiano

CNR institutes

ISN – Istituto di scienze neurologiche