Articolo in rivista, 2018, ENG, 10.1063/1.5047780

Design of new nanocarriers for biomedical applications

Colone, Marisa; Angiolella, Letizia; Vitali, Alberto; Serra, Stefano; Gori, Alessandro; Calcabrini, Annarica; Stringaro, Annarita

Università degli Studi di Roma La Sapienza; Università Cattolica del Sacro Cuore, Rome; Consiglio Nazionale delle Ricerche; Istituto Superiore Di Sanita

One of the main prerequisite of a therapeutic drug is to overcome a series of physiological barriers and it to be less toxic for the human. To this aim, it is necessary to find a carrying vector able to enhance drug internalization and to improve its therapeutic efficacy. Presently, biocompatible and biodegradable nanoparticles (NPs) as some effective drug delivery devices, are widely studied. In order to increase the antimicrobial and antitumor efficacy of different natural products numerous studies are in progress to evaluate different drug delivery systems (cationic liposomes, lysozyme-shelled hollow nanoimicrobubbles and nanoimicrocapsules). This delivery system would have a synergistic and additive effect decreasing the drug resistance reactions too. The present article has tried to review some of the latest research on nanocarriers in clinical care.

AIP conference proceedings 1990

Keywords

nanocarrier

CNR authors

Serra Stefano, Vitali Alberto, Gori Alessandro

CNR institutes

ICRM – Istituto di chimica del riconoscimento molecolare