Abstract in rivista, 2019, ENG, 10.1111/all.13960

House dust mite sensitization prevalence and IgE profiles in two different climatic zones

Alessandri, C.; Wu, A.; Giangrieco, I; Tuppo, L.; Ricciardi, T.; Ciardiello, M. A.; Mari, A.

IBBR, Napoli, CNR; Ctr Associati Allergol Mol; Allergy Data Labs Srl; Ksena Ltd;

Background : Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, Blomia tropicalis are house dust mites (HDM), representing a relevant source of indoor allergens. Their concentration depends upon the indoor environmental conditions and the external climate. To define the sensitization patterns to HDM allergenic proteins and extracts in patients tested for routine allergy diagnosis living in a humid subtropical climate (Hong Kong, HK) and in a Mediterranean climate (Lazio, Italy, IT). Method : The sera of patients living in HK and IT were tested by means of FABER, a nanobead- based multiplex IVD test for specific IgE detection bearing 122 molecular allergens and 122 allergenic ex-tracts. The following HDM molecules and extracts are spotted on the FABER: Der f 1, Der f 2, Der p 1, Der p 2, Der p 7, Der p 9, Der p 10, Der p 23, Eur m 2, Der p and Blo t. Results : Out of 3156 sera tested from patients living in HK (1131) and IT (2015), 1825 resulted to be sensitized to at least one HDM, 812 from HK (72%) and 1067 from IT (53%). Out of the patients sen-sitized to at least one HDM, different sensitization patterns were recorded between the two climate zones: the minimum difference in recognition was observed for Der p 2 (80% in HK and 76% in IT) and Der f 2 (85% in HK vs 80% in IT), whereas the maximum differ-ence was observed for Der f 1 (60% in HK vs 23% in IT). Out of 57 monosensitizations in HK, the most recurring was detected for Blo t (28 sera, 49%), whilst out of 113 monosensitizations in IT, the most recurring was detected for Der p (32 sera, 28%). When analysing the results by number of simultaneously recognized HDM, HK patients sensitizations were largely prevailing vs IT patients for high number of simultaneous HDM sensitization (11 vs 8), whilst the opposite was recorded for IT vs HK patients for lower number of simultaneous HDM sensitization (1 to 4). Conclusion : Different patterns of sensitization to HDM were found in our study when comparing two populations from different cli-mate and geographical area. Considering the need for personalized medicine to be translated into a therapeutic decision, the knowledge about single patient IgE profile is of utmost importance. This implies that the allergy investigation should be carried out in the most com-prehensive manner. FABER test, including molecules and extracts, allows to test the patients' sensitization to the broadest spectrum of available HDM allergens in the routine setting.

Allergy (Cph.) 74 , pp. 373–374

Keywords

allergy, house dust mites, FABER test, climatic zones

CNR authors

Ciardiello Maria Antonietta

CNR institutes

IBBR – Istituto di Bioscienze e Biorisorse

ID: 406143

Year: 2019

Type: Abstract in rivista

Creation: 2019-09-05 11:14:16.000

Last update: 2019-09-12 11:40:42.000

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:406143

DOI: 10.1111/all.13960

ISI Web of Science (WOS): 000480254002268