Articolo in rivista, 2019, ENG, 10.1016/j.fitote.2019.104355

Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity

Djebara A.; Ciavatta M.L.; Mathieu V.; Colin M.; Bitam F.; Carbone M.; Gavagnin M.

Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli, Napoli, Italy; Laboratoire de Chimie et Chimie de l'Environment, Faculté des Sciences de la Matiere, Departament de Chimie, Universitè de Batna-1, 05000, Algeria; Department of Pharmacotherapy and Pharmaceutics, Faculty of Pharmacy, ULB, Campus de la Plaine, Blvd du Triomphe, 1050 Brussels, Belgium; U-CRC, ULB Cancer Research Center, ULB, route de Lennik, 808, 1070 Brussels, Belgium; Faculté de Médecine, Département de Pharmacie, Université de Batna-2, 05000, Algeria.

The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with main related polyacetylenes 1-3 and the already known monoterpene aldehydes 6-10, from the petroleum ether extract of roots. The structure and the absolute configuration of compounds 4 and 5 have been determined by spectroscopic methods as well as by comparison with related known compounds. Polyacetylenes 1-4 inhibited significantly the in vitro growth of a series of cancer cell lines, ranging from 0.3 to 29 ?M, whereas 5 was inactive.

Fitoterapia (Milano. 1934) 138 , pp. 104355–?

Keywords

Eryngium tricuspidatum: Apiaceae, Polyacetylenes, Falcarindiol, Antiproliferative activity

CNR authors

Ciavatta Maria Letizia, Carbone Marianna, Gavagnin Capoggiani Margherita

CNR institutes

ICB – Istituto di chimica biomolecolare

ID: 408503

Year: 2019

Type: Articolo in rivista

Creation: 2019-10-28 17:42:09.000

Last update: 2021-03-31 20:47:24.000

External links

OAI-PMH: Dublin Core

OAI-PMH: Mods

OAI-PMH: RDF

DOI: 10.1016/j.fitote.2019.104355

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:408503

DOI: 10.1016/j.fitote.2019.104355

Scopus: 2-s2.0-85073030347

ISI Web of Science (WOS): 000498290700035