Articolo in rivista, 2019, ENG, 10.3390/genes10100834

A Method for the Structure-Based, Genome-Wide Analysis of Bacterial Intergenic Sequences Identifies Shared Compositional and Functional Features

Lenzini L.; Di Patti F.; Livi R.; Fondi M.; Fani R.; Mengoni A.

Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, Sesto Fiorentino, 50019, , Italy; Istituto Nazionale di Fisica Nucleare, Sesto Fiorentino, 50019, Italy; Centro Interdipartimentale per lo Studio delle Dinamiche Complesse, Sesto Fiorentino, 50019, , Italy; Istituto dei Sistemi Complessi, Consiglio Nazionale delle Ricerche, Sesto Fiorentino, 50019, , Italy; Dipartimento di Biologia, Università degli Studi di Firenze, Sesto Fiorentino, 50019, Italy

In this paper, we propose a computational strategy for performing genome-wide analyses of intergenic sequences in bacterial genomes. Following similar directions of a previous paper, where a method for genome-wide analysis of eucaryotic Intergenic sequences was proposed, here we developed a tool for implementing similar concepts in bacteria genomes. This allows us to (i) classify intergenic sequences into clusters, characterized by specific global structural features and (ii) draw possible relations with their functional features.

Genes (Basel) 10 (10)

Keywords

bacterial gene regulation, clustering method, complex systems, noncoding DNA

CNR authors

Livi Roberto

CNR institutes

ISC – Istituto dei sistemi complessi