Articolo in rivista, 2020, ENG, 10.1016/j.jff.2020.104013

(Poly)phenols and cardiovascular diseases: Looking in to move forward

Claudia Vetrani, Giuseppina Costabile, Marilena Vitale, Rosalba Giacco

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy Institute of Food Sciences, National Research Council, Avellino, Italy

Dietary (poly)phenol intake has been associated with a lower risk of cardiovascular mortality and new events. However, no conclusive data can be drawn from clinical trials evaluating the effects of (poly)phenols on cardiovascular risk factors. In addition, the mechanisms of action behind the beneficial association of (poly)phenol intake with cardiovascular health are not completely understood. Therefore, this perspective aimed to highlight the main methodological limitations that might explain the conflicting results obtained so far. In addition, novel insights on local and systemic effects of (poly)phenols were discussed. Finally, some critical issues to take into consideration in future studies were reported. This more comprehensive approach could represent a strategy to deeply understand the effects of (poly)phenols on human health.

Journal of Functional Foods

Keywords

(Poly)phenols Phenolic metabolites Cardiovascular disease Cardiovascular risk factors Microbiota

CNR authors

Giacco Rosalba

CNR institutes

ISA – Istituto di Scienze dell'Alimentazione