Articolo in rivista, 2020, ENG, 10.1016/j.ijbiomac.2020.08.170

Agarose/ -carrageenan-based hydrogel !lm enriched with natural plant extracts for the treatment of cutaneous wounds

Lorena Anna Ditta (a) , Estella Rao(a) , Fiorenza Provenzano (a) , Jesús Lozano Sánchez (b,c), Radha Santonocito (a), Rosa Passantino (a), Maria Assunta Costa (a), Maria Antonietta Sabatino (d), Clelia Dispenza (a, d), Daniela Giacomazza (a), Pier Luigi San Biagio (a), Romano Lapasin (e)

(a) - Istituto di Biofisica,Consiglio Nazionale delle Ricerche, Via U.LaMalfa, 153, 90146 Palermo, Italy (b) - Department of Food Science and Nutrition, University of Granada, Campus Universitario s/n, 18071 Granada, Spain (c) - Center of Research and Development of Functional Food, Health Science Technological Park, Av.da del Conocimiento s/n, 18100 Granada, Spain (d) - Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Edifcio 6, 90128 Palermo, Italy (e) - Dipartimento di Ingegneria e Architettura, Università degli Studi di Trieste, Piazzale Europa, 34127 Trieste, Italy

Hydrogels for complex and chronic wound dressings must be conformable, absorb and retain wound exudates and maintain hydration. They can incorporate and release bioactive molecules that can accelerate the healing process. Wound dressings have to be in contact with the wound and epidermis, even for long periods, without causing adverse effects. Hydrogel dressing formulations based on biopolymers derived from terrestrial or marine "ora can be relatively inexpensive and well tolerated. In the present article hydrogel !lms composed by agarose (1.0 wt%), -carrageenan at three different concentrations (0.5, 1.0 and 1.5 wt%) and glycerol (3.0 wt%) were pre- pared without recourse to crosslinking agents, and characterized for their mechanical properties, morphology, swelling and erosion behavior. The !lms resulted highly elastic and able to absorb and retain large amounts of "uids without losing their integrity. One of the !lms was loaded with the aqueous extract from Cryphaea heteromalla (Hedw.) D. Mohr for its antioxidant properties. Absence of cytotoxicity and ability to reduce the ox- idative stress were demonstrated on NIH-3T3 !broblast cell cultures. These results encourage further biological evaluations to assess their impact on the healing process.

International journal of biological macromolecules 164 , pp. 2818–2830

Keywords

Agarose/ -carrageenan Blend, Cryphaea heteromalla bryophyte, Wound healing

CNR authors

San Biagio Pier Luigi, Costa Maria Assunta, Passantino Rosa, Giacomazza Daniela

CNR institutes

ID: 433083

Year: 2020

Type: Articolo in rivista

Creation: 2020-09-30 06:43:10.000

Last update: 2021-04-02 11:41:00.000

External links

OAI-PMH: Dublin Core

OAI-PMH: Mods

OAI-PMH: RDF

DOI: 10.1016/j.ijbiomac.2020.08.170

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:433083

DOI: 10.1016/j.ijbiomac.2020.08.170