CNR ExploRA

Articolo in rivista, 2021, ENG, 10.1016/j.apsusc.2021.150795

Laser-Mediated antibacterial effects of Few- and Multi-Layer Ti3C2Tx MXenes

Rosenkranz A.; Perini G.; Aguilar-Hurtado J.Y.; Zambrano D.F.; Wang B.; Niccolini B.; Henriques P.C.; Rosa E.; De Maio F.; Delogu G.; De Spirito M.; Palmieri V.; Papi M.

Department of Chemical Engineering, Biotechnology and Materials, FCFM, University of Chile, Santiago, 8370415, Department of Chemical Engineering, Biotechnology and Materials, FCFM, University of Chile, Santiago 8370415, Chile; Department of Chemical Engineering, Biotechnology and Materials, FCFM, University of Chile, Santiago, 8370415, Department of Chemical Engineering, Biotechnology and Materials, FCFM, University of Chile, Santiago 8370415, Chile; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome, 00168, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, 00168, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome 00168, Italy, , Italy; Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Ningbo, 315201, Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Ningbo, 315201, Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen 208, Porto, 4200-135, INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen 208, Porto 4200-135, Portugal; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, 00168, Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome 00168, Italy; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome, 00168, Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy, , Italy; Mater Olbia Hospital, Olbia, Mater Olbia Hospital, Olbia, Italy; Istituto dei Sistemi Complessi, CNR, Via dei Taurini 19, Rome, 00185, Istituto dei Sistemi Complessi, CNR, Via dei Taurini 19, Rome 00185, Italy; Istituto dei Sistemi Complessi, CNR, Via dei Taurini 19, Rome, 00185, Istituto dei Sistemi Complessi, CNR, Via dei Taurini 19, Rome 00185, Italy

Ti3C2TX nano-sheets (MXenes) with excellent light-conversion capacity have gained importance in treating in-fectious diseases due to their limited bacterial resistance. In this study, we exploit this property to design pho-tothermal antibacterial therapy using few- (FX) and multi-layer (MX) Ti3C2Tx nano-sheets. We demonstrate that FX have a higher cytocompatibility and conversion of light to heat, but MX show a better efficacy in inhibiting growth of S. aureus and E. coli due to MXenes' reversible bacteria trapping. For MX (25 ?g/mL), ?37% of E. coli and ?23% of S. aureus cells survived, while the effect was less pronounced for FX with ?72% of E. coli and ?46% of S. aureus viable cells after treatment. After using 100 ?g/mL of MX, ?11% of E. coli and ?4% of S. aureus survived, while FX had only a mild effect on both species. The NIR laser treatment increased the efficacy of both materials: 100 ?g/mL of MX combined with 5 min laser treatment at 5.7 W cm

Applied surface science 567 , pp. 150795-1–150795-9