Articolo in rivista, 2022, ENG, 10.24820/ark.555019.p011.739
Mingoia, Francesco (1) (2) Panzeca, Giovanna; Vitale, Maria Concetta; La Monica, Gabriele; Bono, Alessia; Lauria, Antonino; Martorana, Annamaria
(1) ISMN-CNR-Sede di Palermo (2) Università degli Studi di Palermo, STEBICEF
A set of variously substituted 1-arylpyrazol-3-one derivatives, including the di-ortho-aryl substituted ones, was synthesized as new potential anticancer compounds. To fulfill this aim, herein a regiospecific synthesis was proposed utilizing a new revisited one pot procedure, starting from commercial anilines and easily accessible 2,5-dimethyl-furan-3-one. In the course of the sequential ordered steps, in some cases, a nitro group displacement by chlorine took place to a minor extent. The in vitro screening against the full panel of similar to 60 human cancer cell lines (NCI) showed a moderate, but promising selective antiproliferative activity against the UO31 renal tumor cell line, only in compounds with the introduction on the phenyl moiety of a -CF3 or two CI groups.
ARKIVOC (Print) (ii), pp. 191–203
Pyrazol-3-ones, antiproliferative activity, nitrogen heterocycles, regiospecific cyclization, NCI screening
ID: 468074
Year: 2022
Type: Articolo in rivista
Creation: 2022-06-09 16:21:28.000
Last update: 2022-07-14 11:54:11.000
CNR authors
External IDs
CNR OAI-PMH: oai:it.cnr:prodotti:468074
DOI: 10.24820/ark.555019.p011.739
ISI Web of Science (WOS): 000800404800010