Articolo in rivista, 2022, ENG, 10.3390/biom12101344

From Small Peptides to Large Proteins against Alzheimer'sDisease.

Pasquale Picone; Tiziana Sanfilippo; Sonya Vasto ; Sara Baldassano; Rossella Guggino; Domenico Nuzzo; Donatella Bulone; Pier Luigi San Biagio; Emanuela Muscolino; Roberto Monastero; Clelia Dispenza; Daniela Giacomazza

1Istituto per la Ricerca e l'Innovazione Biomedica, Consiglio Nazionale delle Ricerche, Via U. La Malfa 153, 90146 Palermo, Italy 2Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, 90128 Palermo, Italy 3Ambulatorio di Nutrizione Clinica ASP Palermo, Via G. Cusmano 24, 90141 Palermo, Italy 4Anestesia e Rianimazione, Presidio Ospedaliero "S. Cimino", 90141 Termini Imerese, Italy 5Istituti Euro-Mediterranei di Scienza e Tecnologia (IEMEST), Via M. Miraglia 20, 90139 Palermo, Italy 6Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via U. La Malfa 153, 90146 Palermo, Italy 7Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, 90128 Palermo, Italy 8Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, Italy

Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (<i>p</i>-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.

Biomolecules 12(10)

Keywords

Alzheimer's disease, Tau protein;, amyloid-beta protein, amyloid fibrillation;, neurofibrillary tangles

CNR authors

Vasto Sonya, San Biagio Pier Luigi, Bulone Donatella, Nuzzo Domenico, Picone Pasquale, Giacomazza Daniela

CNR institutes

IRIB – Istituto per la Ricerca e l'Innovazione Biomedica

ID: 474983

Year: 2022

Type: Articolo in rivista

Creation: 2022-12-14 08:29:36.000

Last update: 2023-01-10 11:42:53.000

External links

OAI-PMH: Dublin Core

OAI-PMH: Mods

OAI-PMH: RDF

DOI: 10.3390/biom12101344

External IDs

CNR OAI-PMH: oai:it.cnr:prodotti:474983

DOI: 10.3390/biom12101344