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Articolo in rivista, 2023, ENG, 10.1039/D2NJ05479E

From CO2 to CS2: a Theoretical Investigation of the Cycloaddition to Aziridines Mediated by Metal-free Porphyrin-based Catalytic Systems

Gabriele Manca, Caterina Damiano, Nicola Panza, Jakub Nagy and Emma Gallo

Department of Chemistry, University of Milan, Via Golgi 19, I-20133 Milan, Italy; Faculty of Science in Department of Chemistry, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic; Istituto di Chimica dei Composti OrganoMetallici, CNR-ICCOM, Via Madonna del Piano 10, I-50019 Sesto Fiorentino, Italy.

A detailed computational analysis of the synthesis of thiazolidine-2-thiones by the CS2 insertion into the three membered aziridine rings is here reported. DFT studies highlighted the feasibility of the atom-efficient process by employing either the metal free binary TPPH2/TBACl system or bifunctional TPPH4Cl2 molecule as the catalytic species. Detailed investigations on the mechanism promoted by TPPH2/TBACl system indicated, as in the analogous cycloaddition of CO2, the pivotal role of adduct between TPPH2 and TBACl salt in the synthesis of both N-aryl and N-alkyl thiazolidine-2-thiones. The latter species can be also obtained by using the eco compatible TPPH4Cl2 catalyst, which is able to simultaneously activate CS2 and aziridine molecules. The comparison of the overall energy gains of the reaction between aziridines and CS2 with respect to the same process involving CO2, revealed that the formation of thiazolidine-2-thiones is more favoured than the synthesis of oxazolidin-2-ones paving the way to develop efficient and eco-compatible synthesis of thiazolidine-2-thiones.

New journal of chemistry (Online) 47 (9), pp. 4306–4312