Articolo in rivista, 2023, ENG, 10.3390/genes14020314

miRNAs: The Road from Bench to Bedside

Giuseppe Iacomino

Institute of Food Sciences, National Research Council, Via Roma, 64, 83100 Avellino, Italy

Abstract: miRNAs are small noncoding RNAs that control gene expression at the posttranscriptional level. It has been recognised that miRNA dysregulation reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operative problems including stability, delivery systems, and bioavailability, still need to be solved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as an innovative class of molecules for upcoming therapeutic applications. This article aims to provide a comprehensive overview of current knowledge on several pending issues and new opportunities offered by miRNAs in the treatment of diseases and as early diagnostic tools in next-generation medicine.

Genes (Basel) 314 (14), pp. 1–14

Keywords

miRNA, circulating miRNA, theranostic biomarkers, RNA-based therapeutic, translational medicine, personalized mdicine

CNR authors

Iacomino Giuseppe

CNR institutes

ISA – Istituto di Scienze dell'Alimentazione