Articolo in rivista, 2022, ENG, 10.3390/app12188990

An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives

Srivastava, Ankit; Rikhari, Deeksha; Pradhan, Biswajita; Bharadwaj, Kaushik Kumar; Gaballo, Antonio; Quarta, Alessandra; Jena, Mrutyunjay; Srivastava, Sameer; Ragusa, Andrea

Motilal Nehru Natl Inst Technol; Berhampur Univ; Sangmyung Univ; Guwahati Univ; Inst Nanotechnol; Univ Salento

Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. This review focuses on various neuropeptides and their potential utility as drug targets by different inhibitors as a recently identified approach to cancer prevention, with particular emphasis on colorectal cancer.

Applied sciences 12 (18)

Keywords

neuropeptide, receptor, inhibitors, cancer, therapeutic agents, bombesin, neurotensin, vasoactive intestinal peptide, substance P

CNR authors

Gaballo Antonio, Quarta Alessandra

CNR institutes