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Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population representative studies with 141 million participants.

Background Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to 2022 in diabetes prevalence and treatment for 200 countries and territories. Methods We used data from 1108 population-representative studies with 141 million participants aged 18 years and older with measurements of fasting glucose and glyca...

Enhanced G-quadruplex ligand screening exploiting high-throughput synchrotron radiation circular dichroism

G-quadruplexes (G4s) represent rigid arrangements of DNA/RNA, composed of stacked guanine tetrads held together by Hoogsteen-type hydrogen bonds, and stabilized by metal cations, predominantly K+ . These structures can adopt parallel, anti-parallel, or hybrid topologies depending on the orientation of connecting strands, exhibiting distinct CD spectral features useful for diagnostic purposes [1]. Their presence in crucial genomic regions like proto-oncogenes and telomeres, along with their co...

Optimization of a TREM2 receptor inhibitor peptide

Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor regulating the inflammatory response and involved in neurodegenerative, chronic and autoimmune diseases. TREM2 is an orphan receptor, and the research of new ligands has recently become a hot topic. In this context, the peptide sequence IA9 (H-IFLIKILAA-OH) has been rationally designed for inhibition of TREM2 [1]. In order to deeper analyze the mechanism of interaction with TREM2 and select molecules with specific ...

Effect of lipid peroxidation on protein conformational stability

Lipid oxidation can occur in vivo during oxidative stress and redox imbalance conditions, such as inflammation or environmental toxicity. This process generates reactive oxygen species (ROS), including the superoxide anion and hydroxyl radical within cells. Unsaturated fatty acids in tissues are particularly prone to oxidation by these ROS through non-enzymatic mechanisms. Lipid peroxidation, operating via a chain mechanism, produce a wide range of oxygenated small molecules, which significan...

The role of β-hairpins in aggregation of β-amyloid erived peptides

Alzheimer’s disease (AD) is one of the most widely recognized and prevalent neurodegenerative conditions in today’s society. However, despite its prevalence, effective pharmacological treatment is not currently available, leaving only palliative care options as the most helpful course of action. The pathogenesis of Alzheimer's disease (AD) involves the formation of proteinaceous plaques due to the aggregation of originally soluble oligomers of amyloid-β peptides [1] . These oligomers have bee...

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Prodotti recenti

Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population representative studies with 141 million participants.

Enhanced G-quadruplex ligand screening exploiting high-throughput synchrotron radiation circular dichroism

Optimization of a TREM2 receptor inhibitor peptide

Effect of lipid peroxidation on protein conformational stability

The role of β-hairpins in aggregation of β-amyloid erived peptides

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